How VEREGEN® (sinecatechins) Ointment, 15% Works and What to Expect

It has not yet been proven precisely how VEREGEN® works to successfully treat external genital and perianal warts. The main ingredient—an extract taken from green tea leaves—is believed to have antioxidative properties, but the mechanism of action of VEREGEN® is unknown.

Here are answers to some of the questions you may have about what to expect with VEREGEN® treatment.

Will VEREGEN® work for me?

VEREGEN® has been clinically proven to help clear up external genital and perianal warts. In two clinical studies, most people (53.6%) who applied VEREGEN® 3 times a day for up to 16 weeks had complete clearance of genital and perianal warts (vs 35.3% of people who applied vehicle). In these studies, treatment continued for 16 weeks or less, depending on how quickly the genital and perianal warts cleared.

Will the warts come back?

In the clinical studies described above, people who used VEREGEN® and had complete clearance of external warts were re-checked 12 weeks after their treatment ended. More than 90% of people who used VEREGEN® and more than 90% of people who used vehicle had no recurrence of warts at that time.

(Remember: HPV can stay in the body for weeks or months without symptoms so warts could come back in the future.)

Will I have side effects?

People may experience redness, swelling, sores, rash with blisters, burning, itching, pain, or hard spots while using VEREGEN®. These side effects will likely peak by Week 2 of treatment. Very few people in the clinical studies stopped using VEREGEN® because of side effects. Be sure to tell your doctor if you get any more severe side effects.

Can I be sexually active while using VEREGEN®?

VEREGEN® does not prevent the transfer of HPV. You need to be very careful, but it is possible to have protected sex using a condom for vaginal, anal, and oral sex. Be sure to wash off all the ointment with warm soap and water beforehand. Avoid sexual contact when VEREGEN® is on your skin. After sex, wash your hands and the treatment area, then reapply VEREGEN®.

Can VEREGEN® affect certain contraceptives?

The use of VEREGEN® may weaken condoms and vaginal diaphragms. Be sure to wash all of the ointment off with warm soap and water before using either of these options.

VEREGEN® is indicated for the topical treatment of external genital and perianal warts (Condylomata acuminata) in patients 18 years and older.

Important Safety Information

Do not use VEREGEN® Ointment, 15% if you are allergic to any ingredient in this product. Do not use VEREGEN® Ointment, 15% for warts in the vagina, cervix, or inside the anus. Avoid contact with your eyes, nostrils and mouth while ointment is on your finger(s).

Avoid use of VEREGEN® on open wounds. Do not expose skin that has been treated with VEREGEN® to the sunlight, sunlamps or tanning beds. Tell your doctor if you are using any other type of skin product on the area to be treated. Avoid sexual contact (genital, anal or oral) when VEREGEN® Ointment, 15% is on your genital or perianal skin. If you do choose to have sexual contact, you must wash off the ointment carefully before having protected sexual contact as the ointment may weaken condoms and vaginal diaphragms.

Be sure to tell the doctor if you have a weak immune system, if you are pregnant or nursing a baby, or if you have used VEREGEN® before. Avoid using this product in patients younger than 18 years of age or for longer than 16 weeks. If your warts do not go away or come back after treatment contact your doctor.

The most common side effects with VEREGEN® Ointment, 15% are local skin and application site reactions including: redness, swelling, sores, rash with blisters, burning, itching, pain, hard spots.

For more information, consult your healthcare professional.

You are encouraged to report negative side effects of prescription drugs to the Food and Drug Administration (FDA). Please visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you have a product complaint about VEREGEN®, please call PharmaDerm customer service at 1-800-525-8747.

The information on this website should not take the place of talking with your healthcare professional. If you need medical information, please talk to your healthcare professional.

Please see link to full Patient Information. VEREGEN® (sinecatechins) Ointment, 15% Patient Information.

Please see link to full Prescribing Information. VEREGEN® (sinecatechins) Ointment, 15% Full Prescribing Information.